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Dallas Cowboys at San Francisco 49ers: Predictions, picks and odds for NFL Week 8 game

It may no longer be the 1990s, but a showdown between the San Francisco 49ers and Dallas Cowboys is always a treat. While neither team has lived up to expectations thus far, both teams are still in the hunt for a playoff spot and a division title.

Of course, the Cowboys will have a massive edge this Sunday night. The 49ers have been decimated with injuries including a season-ending ACL tear to star receiver Brandon Aiyuk. Furthermore, the Cowboys are coming off their bye, which makes this the second weekend in a row that the 49ers will face a team with an extra week of rest.

While the 49ers have started a season 3-4 rather recently and still found success in the postseason, they have not started 3-5. This would be unprecedented waters that the 49ers may not be able to recover from.



Here are our experts’ predictions for this highly-anticipated Week 8 matchup.

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49ers vs. Cowboys odds, moneyline, over/under

The 49ers are favorites to defeat the Cowboys, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2024 including the ESPN BET app and Fanatics Sportsbook promo code.

Spread: 49ers (-4.5) Moneyline: 49ers (-225); Cowboys (+180) Over/under: 46.5

Not interested in this game? Our guide to NFL betting odds, picks and spreads has you covered with Thursday Night Football odds and Monday Night Football odds.

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NFL Week 8 odds, predictions and picks

Lorenzo Reyes: Cowboys 21, 49ers 20

Honestly, I kind of hate that I’m making this pick, but the 49ers are so seriously banged up at the skill positions that this feels like a game Dallas needs to have. There is the whole thing where the Niners always dominate Dallas, but the Cowboys are coming off their bye. Call me crazy, but I’m sticking to it.

Tyler Dragon: 49ers 23, Cowboys 21

Two teams going in the wrong direction. Is the 49ers’ Super Bowl window closed? San Francisco’s dealt with a multitude of injuries, while the Cowboys have weaknesses all over the field. The Cowboys have lost three straight versus the 49ers.



Richard Morin: 49ers 30, Cowboys 27

The temperature is reaching a fever pitch in Dallas. The 49ers are due for a big win. I think a last-second field goal decides this one. 

Jordan Mendoza: 49ers 22, Cowboys 20

The 49ers got dealt big blows with top receiving options dealing with injuries and illness. Despite that, the defense should hold off the Dallas offense enough to get a much-needed home victory.