The San Francisco 49ers and Minnesota Vikings play Sunday, Sept. 15, at U.S. Bank Stadium in a game on the NFL Week 2 schedule.
Which team will win the Week 2 NFL game?
Check out these NFL Week 2 picks and NFL Week 2 predictions for the game, which can be seen at 10 a.m. MST on CBS (stream with free trial from FUBO).
The 49ers are a 5.5-point favorite over the Vikings in NFL Week 2 odds for the game, courtesy of BetMGM Sportsbook.
San Francisco is -250 on the moneyline, while Minnesota is +200.
The over/under (point total) is set at 45.5 points.
NFL Week 2 picks: Bills vs Dolphins | Raiders vs Ravens | Chargers vs Panthers | Saints vs Cowboys | Buccaneers vs Lions | Colts vs Packers | Browns vs Jaguars | 49ers vs Vikings | Seahawks vs Patriots | Jets vs Titans | Giants vs Commanders | Rams vs Cardinals | Steelers vs Broncos | Bengals vs Chiefs | Bears vs Texans | Falcons vs Eagles | The Arizona Republic’s predictions
Watch 49ers at Vikings live with FUBO (free trial)
The Arizona Republic: 49ers 27, Vikings 17
Jeremy Cluff writes: “The Vikings impressed in Week 1, but it was against the New York Giants. Beating the 49ers will be much more difficult.”
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Bookies.com: Bet the 49ers to cover vs Vikings in NFL Week 2
Bill Speros writes: “The 49ers are favored for a return to the Super Bowl this season and the No. 2 pick to win it, behind Kansas City. The Vikings drafted J.J. McCarthy from the national champion Michigan Wolverines in April. But Sam Darnold got the QB1 spot after McCarthy’s injury and handled his business against Not-So-Big Blue in Week 1. The 49ers return a defense held the Chiefs to 19 points in regulation during Super Bowl 58. The post-Super Bowl-loss hangover is the most lethal in sports. But the Niners are stacked on both sides of the ball. And they covered in 6 of 9 road games last season. This line has moved a point toward the Niners. A nice discount here.”
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Sports Betting Dime: 49ers 26.5, Vikings 11.6
The site’s formula predicts that the 49ers will win the NFL Week 2 game against the Vikings.
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ESPN: 49ers have a 65.2% chance to beat Vikings on Sunday
The site gives the Vikings a 34.5% shot at winning the NFL Week 2 game.
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Dimers: 49ers 26, Vikings 21
It writes: “According to our analysis, the 49ers are more likely to beat the Vikings in the NFL game at U.S. Bank Stadium on Sunday.”
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